Osteoarthritis in Dogs – Joint Support with Nutraceuticals

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Osteoarthritis (OA) is a progressive, degenerative disease of the joints. It is one of the most common chronic diseases that affect dogs. By some estimates, 20% of dogs of all ages are affected by OA.

What causes OA in dogs?

The causes of OA in dogs are many and varied. There may be genetic causes or predispositions. There may be a traumatic injury. Overweight and obesity contribute to OA by way of repetitive overloading of the joints, leading to damage over time.

One common OA management tool is nutraceuticals for joint health.

Regardless of the specific causes of a particular dog’s OA, the goal is long-term, lifetime management rather than a cure. A comprehensive, multimodal management approach to OA allows your veterinarian to target specific aspects of OA. By choosing several targets rather than a single focus for treatment, therapies complement one another, creating a superior outcome. One common OA management tool is the addition of nutraceuticals for joint support.

What are nutraceuticals?

The word “nutraceutical” combines the words “nutrition” and “pharmaceutical.” A nutraceutical is a food or food product that reportedly provides health and/or medical benefits. Nutraceuticals are often presented as compounds that can provide protection against chronic disease. Nutraceuticals may contain isolated nutrients, dietary supplements, or herbal products. Another definition of a nutraceutical is a fortified food or dietary supplement that provides health benefits.

Your veterinarian can help you choose nutraceuticals that have been evaluated and have yielded positive effects in dogs.

Nutraceuticals are not subjected to the same testing and regulation as pharmaceuticals. For this reason, healthy skepticism is a good idea when considering nutraceuticals for your dog. Investigators are conducting clinical studies to evaluate the role of certain nutraceuticals to help dogs with OA. Your veterinarian can help you choose nutraceuticals that have been evaluated and have yielded positive effects.

What are some nutraceuticals I might consider to help my dog with OA?

Several nutraceuticals have shown positive results for managing OA. If your dog is a good candidate for any of these nutraceuticals, your veterinarian can help you make a good choice regarding manufacturer, dosage, and formulation.

Omega 3 Fatty Acids

One important strategy for interrupting the progression of OA is to choose a nutritional profile that has been evaluated in clinical trials to help dogs with OA. Good joint-support diets are rich in the omega-3 fatty acid EPA (eicosapentaenoic acid), which helps control joint inflammation and blocks the enzymes that break down cartilage. Research shows that high levels of EPA help to stop cartilage from degenerating. EPA can also be delivered as a supplement, either in liquid or capsule form. There are several reputable manufacturers of omega-3 fatty acids for pets.

Findings from human studies suggest that omega-3 fatty acids may provide benefits beyond joint support; however, more research needs to be performed to determine if the same benefits may apply to dogs.


Microlactin is a milk protein extracted from the milk of cows that inhibits inflammation regardless of the cause of that inflammation. Research supports the use of microlactin in dogs with osteoarthritis. OA has an inflammatory component, which is why nonsteroidal anti-inflammatory drugs (NSAIDs) play such an important role in managing OA. Microlactin works differently in the body than NSAIDs and corticosteroids do, with no evidence of gastrointestinal (GI) irritation.

Incorporating microlactin into an OA multimodal management plan may help counteract the inflammation of OA while decreasing the side effects that are common with NSAIDs, allowing your veterinarian to decrease or even discontinue the use of an NSAID. It takes about 2 weeks for microlactin to have maximal effects, so veterinarians generally overlap microlactin and the NSAID for 2 to 3 weeks before decreasing the NSAID dose.


Despite the popularity of glucosamine/chondroitin supplements, we are still waiting for good research to support definitive benefits. That said, low-molecular-weight chondroitin appears to have a positive effect in some dogs. Unfortunately, we cannot yet predict which individuals will benefit from this supplement. It may be worth considering a trial treatment using a supplement with low-molecular-weight chondroitin.


ASU stands for “avocado and soybean unsaponifiables” and is an extract from avocado and soybean oils. ASU seems to complement the effects of glucosamine and low-molecular-weight chondroitin. It appears to reduce inflammation involved in cartilage degeneration and thus has a positive effect in canine OA patients.

Can I just pick up nutraceuticals/supplements for my dog at the health store or human pharmacy?

Your veterinarian is your best partner when choosing the most appropriate nutritional profile and supplements for your dog with OA.

Despite the explosion of interest and research in the role of nutrition and nutraceuticals in pets, our understanding of these complex factors and relationships is still in its infancy. The preliminary science of nutraceutical use in dogs with OA is very exciting, but we need to be careful to “follow the data” as much as possible. Your veterinarian is your best partner when choosing the most appropriate nutritional profile and supplements for your dog with OA and can recommend where to purchase them.

Robin Downing, DVM, CVPP, CCRP, DAAPM
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